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In amyloid precursor protein plus presenilin-1 (APP/PS1) mice, Nrf2 overexpression caused by antioxidant therapy has been demonstrated to improve neuronal apoptosis, increase thioredoxin-1 (TRX-1), and prevent the formation of NLRP3 inflammatory bodies [109]

B12 supplements can be taken at any time of day with or without food

doi:10.1016/S0302-2838(02)00354-8

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