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[5] Beyond sodium-channel antagonism, systemic lidocaine exhibits anti-inflammatory and antihyperalgesic properties attributed to inhibition of G-protein-coupled receptors, modulation of NMDA-mediated excitatory transmission, suppression of neutrophil priming, and attenuation of central glial activation

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however, in ITT analysis, all recruited patients in the study were included in the analysis

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Our findings are consistent with previous studies that demonstrating the same trajectory in male Sprague Dawley rats (Cameron et al., 1993