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Rosenstock, J., Allison, D., Birkenfeld, A

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Factorial experimental designs with single-compound and combined-compound treatment arms, alongside vehicle controls, allow researchers to statistically distinguish independent compound effects from any combination-specific outcomes on NAD+ pathway and mitochondrial redox endpoints, a standard approach in multi-compound cellular metabolism research.

In Arabidopsis, HDA19 and HDA6 separately interact with the evolutionarily conserved SIN3-like (SNL) proteins (SNL1 to SNL6), HDC1/RXT3, and MSI1 to form SIN3-type HDAC complexes (Hennig et al, 2003

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