Haas RH, Marsden DL, Capistrano-Estrada S, Hamilton R, Grafe MR, Wong W, et al
Following IcoSema administration, the competition for albumin binding between icodec and semaglutide results in a greater fraction of free, unbound semaglutide at the injection site
Storage requirements differ between compounds
The peptide itself is typically administered subcutaneously, where it is absorbed into the bloodstream, distributed through the body, and then cleared by enzymatic degradation and renal excretion
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