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Another study investigated the beneficial effect of BBR in an in vivo diabetic mouse model and in vitro pancreatic beta cell NIT-1 high glucose treated to induced diabetic condition

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In a similar way as low-intensity electric field, piezoelectric system stimulation inhibits the cell proliferation due to the upregulation of gene encoding Kir3.2 inward rectifier potassium channels, causing disturbance in Ca 2+ homeostasis and mitotic spindle organization

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