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In preclinical and cell culture research, KPV demonstrates suppression of pro-inflammatory cytokines IL-6, IL-1, and TNF- through melanocortin receptor pathway activation

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Its molecular target is nicotinamide N-methyltransferase (NNMT), a cytosolic S-adenosyl-L-methionine-dependent methyltransferase that converts nicotinamide to 1-methylnicotinamide, consuming SAM and releasing S-adenosylhomocysteine

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