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148,149 Proliferating cancer cells exhibit aerobic glycolysis, leading to a shift in glucose carbon away from the TCA cycle, which results in the increased use of glutamine to fuel anabolic processes to support rapid cell growth with increased NADPH and ammonia generation

Genetic variants affecting GIP or GLP-1 receptor function might identify patients most likely to benefit from dual agonism

External Validity The Polish Study on Increlex included Polish patients treated with mecasermin for SPIGFD

Headaches linked to GLP-1 use are typically mild to moderate, often resolve within days to weeks, and tend to cluster during the dose-escalation phase rather than persist throughout treatment

Cagrilintide vs Semaglutide: Which GLP-1 Peptide Is Better for Weight Loss