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Tirzepatide's simultaneous GIPR and GLP-1R engagement generates two spatially distinct cAMP pools that converge on EPAC2, producing a larger net insulin secretory response than single-receptor stimulation at equivalent total cAMP levels [18]

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(2015) showed that very low concentrations of GLP1 (1 pM) result in the generation of diacylglycerol, interpreted to be secondary to G q mediated activation of PLC

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