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The system can be activated by antigen-antibody complexes (classical pathway) and by other components, e.g., bacteria (alternative pathway)

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10.1016/j.cmet.2014.09.018 46 ForetzM.GuigasB.ViolletB

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Considering TNF-, a type II transmembrane protein with an intracellular N terminus and signalling potential both as a membrane-integrated protein and a soluble cytokine released after proteolytic cleavage [386, 387], the activation of its receptor (TNFR) led to the recruitment of intracellular adaptor proteins that activate multiple signal transduction pathways [387, 388]