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By potentially modulating the central nausea response and simultaneously preventing the nutrient deficiencies that GLP-1 therapy can create, B12 helps patients stay on their prescribed dosing schedule without the interruptions and dose reductions that nausea typically forces

The other, in whom only 5% is available to cells, is not

In a 23-week trial, subjects taking 1mg daily lost an average of 2.8kg compared to 0.8kg for placebo

10.1371/journal.pmed.1000097 [DOI] [PMC free article] [PubMed] [Google Scholar] NIHR (2025)

Vitamin B12 Supplementation Dietary Changes Addressing Underlying Causes Monitoring Lifestyle Modifications Follow-up Care Vitamin B12 Supplementation Vitamin B12 supplementation is the most common treatment used to relieve the symptoms of deficiency

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