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Suggesting that the C-terminal sequence differences between exendin-4 and lixisenatide might impact on these cellular processes, a limited evaluation in our earlier study implied that lixisenatide displays reduced signalling potency and insulinotropism compared to exendin-4 (Jones et al., 2018b)

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Further information on the stability and aggregation state not only in aqueous suspension but also in culture media would improve the overall interpretation, especially since the protein corona has a significant effect on surface charge, aggregation state, and thus the final biological outcome

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