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Aspalathin, a C-Glucosyl Dihydrochalcone from Rooibos Improves the Hypoglycemic Potential of Metformin in Type 2 Diabetic (Db/db) Mice

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In addition, stem-like features can be acquired de novo by non-CSCs in response to environmental stimuli such as hypoxia, inflammation, or therapeutic pressure, indicating that CSCs may represent a dynamic functional state rather than a static subpopulation

Inhibition of key ferroptosis regulators like acyl coenzyme ACSL4, GPX4, and Nrf2 may lead to unintended consequences, including disruptions to cellular homeostasis, thereby posing potential risks to therapeutic safety