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Genotype, enzyme activity, glutathione level and clinical phenotype in patients with glutathione synthetase deficiency

Experiments in animals with uniformly labeled 13C-glutamine demonstrated that glutathione was enriched with five 13C atoms, indicating that glutamine is the primary source for glutathione synthesis [11]

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Traditional oral glutathione supplements face challenges in absorption due to their poor stability and low bioavailability in the digestive tract