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A meta-analysis of 27 randomised controlled trials found that berberine significantly reduced fasting blood glucose, HbA1c, triglycerides, total cholesterol, and LDL cholesterol

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In the long term, however, things can get more serious

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Neuroimaging studies have consistently demonstrated reduced D2R availability, reflected by decreased binding potential, in key striatal and extrastriatal regions of obese individuals, supporting an association between obesity, central dopaminergic hypofunction, and dysregulated prolactin homeostasis ( 5 Mechanisms by which obesity may promote hyperprolactinemia We have systematically analyzed the potential mechanisms by which hyperprolactinemia promotes obesity