You should not use GLP-1 medications if you have: Personal or family history of medullary thyroid cancer Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Previous severe allergic reaction to semaglutide or liraglutide Current pregnancy or planning to become pregnant History of pancreatitis (requires careful evaluation) Severe gastrointestinal disease Additionally, these medications are not typically recommended for patients under 18 years old, though Saxenda has some pediatric approval for adolescents 12 and older with obesity
How much weight can I expect to lose with GLP-1 treatment
Easily digestible: A sensitive stomach needs foods that can be broken down easily, such as lean proteins, healthy fats in moderation, and low-spice and low-grease ingredients
Patient safety & quality control Compounded GLP-1 drugs have had quality variability and even unsafe/illegal versions in the market FDA is trying to ensure patients get standardized, approved formulations This aligns with FDAs core principle: approved drugs = known safety, dosing, manufacturing controls 2) Prevents copycat mass production Compounding is legally meant for special cases, not large-scale alternatives The GLP-1 boom led to industrial-scale compounding (especially via telehealth) FDA is essentially saying: this has gone beyond its intended use To me, it should be done in combination with large scale initiatives to significantly improve access and affordability
Marker genes were identified using FindAllMarkers R package focusing on genes expressed by more than 10% of cells within a cluster and with a log fold change greater than 0.26
McCord JM, Fridovich I (1969) Superoxide dismutase
