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Participants were randomly assigned to receive either semaglutide (0.25 mg/week for 4 weeks, 0.5 mg/week for 4 weeks, and 1.0 mg for 1 week) or placebo over nine weeks of outpatient treatment

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Dehydration Risk : The combination of reduced fluid intake, potential fever, and GLP-1-related effects on appetite creates a higher dehydration risk during illness

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Phase 1 trial of ALRN-6924, a dual inhibitor of MDMX and MDM2, in patients with solid tumors and lymphomas bearing wild-type TP53