It is one of several ghrelin analogs developed in recent decades, and research has shown that it has positive effects on various bodily functions, including heart muscle cells, memory formation, scar formation, sex motivation, and neurons involved in Parkinsons disease
The efficacy of setmelanotide may not be sufficient for POMC-MC4R deficient patients because body weight reduction ratio of semaglutide and tirzepatide were 12.4 and 17.8%, respectively in clinical study as compared with that of setmelanotide, 5.2% [[18, 19, 23]]
But that framing misses something important: These aren't two versions of the same medication, and they work through completely different mechanisms
Biochem Biophys Res Commun 298:779784 Burcelin R, Da Costa A, Drucker D, Thorens B (2001) Glucose competence of the hepatoportal vein sensor requires the presence of an activated glucagon-like peptide-1 receptor
This can work
Treatments like RF, ultrasound, or fillers help restore firmness