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Signs of histological anaplasia (cellular-nuclear polymorphism, mitotic activity, and foci of necrosis) do not correlate with the prognosis [47, 48]

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In conclusion, while the FRAP assay is simple and economical, its results should be interpreted cautiously, particularly in comparison to other assays, due to its limitations in addressing reaction kinetics, specificity, and interferences (Magalhaes et al