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Upon cellular stress, characteristic of ASD [158], ROS production and elevated intracellular Ca 2+ concentration trigger mPTP opening leading to mitochondrial membrane permeabilization (MMP) [181], initiating apoptosis and necrosis [269], and regulating the activity of autophagy [270, 271]

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Inhibition of NO-synthase (NOS) that causes decrease in local NO production, impaires gastric microcirculation and aggravates gastric lesions induced by noxious agents (12,13)

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In 2006, Bruno et al

o Pump one to two times into each nostril