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In an additional 30-week placebo-controlled study of patients with type 2 diabetes inadequately controlled with metformin comparing the maintenance of sitagliptin 100 mg versus withdrawal of sitagliptin when initiating basal insulin therapy, the event rate and incidence of documented symptomatic hypoglycemia (blood glucose measurement 70 mg/dL) did not differ between the sitagliptin and placebo groups

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These findings suggest that tirzepatide may have favorable effects on cardio metabolic risk variables such as blood pressure, waist circumference, and lipid profile [77]

Leptin receptorexpressing nucleus tractus solitarius neurons suppress food intake independently of GLP1 in mice

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