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Several research groups have attempted to delineate the underlying mechanisms of irAEs, as curated by the authors of the Cancer Immunology Research paper below

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Patients with PAH have lower transcriptional levels of GPX3 in lung tissues, identifying GPX3 as a hypoxia-induced metabolism-associated hub gene, which could provide insight into the molecular mechanisms of hypoxic PAH and potential therapeutic targets [108]

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An extensive literature search was conducted up to January 2024 across databases such as PubMed, Scopus, and Web of Science

Front Immunol 2023;14:1148209.ArticlePubMedPMC 7