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Higher concentration doesn't automatically mean better results and can increase irritation risk
In certain instances, once drug exposure (e.g., concentration in the endolymph or perilymph) of a drug reaches steady state, the concentration of the drug in the endolymph or perilymph stays at or about the therapeutic dose for an extended period of time (e.g., one day, 2 days, 3 days, 4 days, 5 days, 6 days, 1 week, 2 weeks, 3 weeks, a month, two months, three months, six months, or one year)
& Lewis, K
The positive effects may come with trade-offs we have not measured
The pineal gland produces melatonin, the hormone that regulates sleep-wake cycles