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CYP7A1 is simultaneously inhibited by an FXR-small heterodimer partner (SHP), which is the downstream target of FXR in the liver, whereas FXR in enterocytes inhibits CYP7A1 activation in hepatocytes by secreting fibroblast growth factor 19 (FGF19) and binding to fibroblast growth factor receptor 4 (FGFR4) on the hepatocyte membrane (77)

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His rambling, hour-long speech began with grudging admiration for a press corps he has attacked, sued and subpoenaed, before veering into asides and insults

High ChaC1 expression also serves as a biomarker for adverse outcomes in gastric adenocarcinoma (72), corpus endometrial (73) and breast cancer (74) and uveal melanoma (75)