GLP-1 plays an important role in glucose homeostasis and is secreted into the hepatic portal system in response to elevated glucose levels from food intake 10 , stimulating insulin synthesis and release from the pancreas 11
The problem inherently is that were not quite sure what it is that causes all this benefit
7 Comparison with other drugs Some clinical studies have used other metabolic medications and compared their effects on liver diseases to those of GLP-1RAs
In high-fat-fed rats, [dA(2)]GLP-1/GcG reduced body weight nonfasting plasma glucose, and boosted circulating plasma insulin concentrations when given twice daily for 21 days
Petrie MC, Borlaug BA, Butler J, Davies MJ, Kitzman DW, Shah SJ, et al
For details on known side effects, see our retatrutide side effects guide