p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8(+) T cells
FIGURE 5 Next, we focused on antioxidant enzymes because they primarily regulate the level of ROS, a major cause of oxidative stress
And then the cycle starts again
FIGURE 7 The strong role of severe oxidative stress, reduced antioxidant defenses like GSH with increased lipid peroxidation and malondialdehyde generation (213), lipid, protein and DNA oxidation with increased apoptosis and necrosis in atherosclerosis as a major cause of cardiovascular diseases and stroke, supports the use of complementary and alternative medicines, dietary supplements, and antioxidants with hardly any adverse effect, able to restore homeostasis reversing oxidative stress (214)
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10.1016/j.tibs.2017.02.007 30 De MaioA.VazquezD