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[DOI] [PMC free article] [PubMed] [Google Scholar] 25.Gojkovic S., Krezic I., Vranes H., Zizek H., Drmic D., Batelja Vuletic L., Milavic M., Sikiric S., Stilinovic I., Simeon P., et al

Uses Essential cofactor of fatty acid metabolism

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These data indicate that mutant chondrocytes reduce ER oxidative protein folding to avoid excessive ROS production, which can cause oxidative protein damage

However, the weight loss observed in the SELECT study (9.4%) was lower than that seen in previous STEP studies.23 The study design, which was not focused on obesity, may have influenced the lower-than-expected weight reduction, which did not parallel the trend in MACE reduction

Luoni M, Giannelli S, Indrigo MT, Niro A, Massimino L, Iannielli A, et al