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GLP-1 meds curb your appetite by slowing digestion, and that same slowdown leaves stool hard, dry, and stuck

As of January 2026, 13 states cover tirzepatide and other GLP-1 medications for weight loss

Its relatively small size allows it to interact directly with enzymes rather than acting through peptide receptors

Symptoms of high estrogen include water retention, mood changes, decreased libido, and in some cases, breast tissue sensitivity or gynecomastia

It could be microscopic contaminants or byproducts from a shoddy synthesis process in a low-quality peptide