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In the UK Prospective Diabetes Study Group (UKPDS), metformin showed a significant reduction in cardiovascular events (MI and stroke) or all-cause mortality compared with diet or chlorpropamide or insulin (Table 1 summarizes the cardiovascular effects of metformin as well as those of all other anti-diabetic agents discussed in this review

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L-Arginine Research Summary Research on L-arginine shows clear evidence for increasing nitric oxide production and temporary vasodilation