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Safety and efficacy of glucagon-like peptide-1 receptor agonists in children and adolescents with obesity: a meta-analysis

First-line interventions focus on lifestyle modification, including dietary changes targeting a 600 kcal/day deficit, increased physical activity (aiming for 150 minutes of moderate-intensity exercise weekly), and behavioural support programmes

Then somewhere around month five or six, things level out

Koudstaal T, Funke-Chambour M, Kreuter M, Molyneaux PL, Wijsenbeek MS

Additionally, decentralised trials are becoming increasingly popular

While sales of weight loss drugs are currently stratospheric, sometimes a seemingly isolated event such as a lawsuit can set in motion cascading long-term effects