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However, an analysis of the percent change from baseline in body weight was performed at week 208 and the estimated treatment difference (based on the in-trial period) between semaglutide 2.4 mg and placebo was 8.7% (95% CI, 9.42% to 7.88%)

This is often a localized immune response

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The bacteria must be present, active, and have sufficient time and substrate to produce meaningful amounts of butyrate