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Neurological Neurological complications of ICIs (headache, myasthenia gravis, peripheral neuropathy, meningitis, and encephalitis) are uncommon ( 1%) (32, 77, 184, 202, 203)

In particularly sensitive individuals, the consumption of a few cups of coffee may cause cardiac arrhythmias, but in most people, parenteral administration of high doses of coffee causes only tachycardia

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Perhaps the higher levels of progesterone may be supportive of cortisol production as a means of providing negative feedback to inhibit continued production of norepinephrine from the SNS

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