In detail, it up-regulated level of acetylated H3K27 induced by LAC that binds to the glutamate receptor metabotropic 2 (GRM2) promoter and acetylation of the NF-B p65 subunit, which enhanced the transcription of the GRM2 gene encoding mGlu2 receptor in the hippocampus and prefrontal cortex (86)
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Vitamin C also accelerates collagen production, which has an important role in healing
In contrast, chronic elevations in TMAO, a metabolite derived from LC, have been linked to an increased risk of atherosclerotic cardiovascular disease (ASCVD), particularly in older adults with compromised renal function [64, 65]
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Treatment with hydroquinone has resulted in positive findings for genetic toxicity in the Ames assay in bacterial strains sensitive to oxidizing mutagens, in in vitro studies in mammalian cells, and in the in vivo mouse micronucleus assay
