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In type 2 diabetes trials, retatrutide showed greater improvements in body weight and HbA1c than reference GLP-1 receptor agonists such as dulaglutide

Inject the medication exactly as instructed by the medication guide or care team

Common adverse effects of GLP-1 receptor agonists include gastrointestinal symptomsparticularly nausea, vomiting, diarrhoea, and constipationwhich typically diminish over time

Clinical Markers Higher-Risk Groups Individuals with obesity at baseline Low sun exposure Darker skin phototypes Low dietary fat intake 4.7 Fat-Soluble Vitamins (A, E, K) Physiological Role These vitamins are essential for: Vision (A) Antioxidant defence (E) Coagulation (K) Cellular signalling They require dietary fat and intact bile flow for absorption

Microbial metabolitespostbioticsalso serve as potent regulators of GLP-1 signaling (Tolhurst et al., 2012)

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