FOXO4-DRI Key Research Facts Full name: FOXO4 D-Retro-Inverso peptide (FOXO4-DRI) Classification: Cell-penetrating senolytic peptide FOXO4/p53 protein-protein interaction inhibitor Design: D-retro-inverso isoform of FOXO4s p53-binding domain reversed sequence with all D-amino acids Binding target: p53 transactivation domain 2 (TAD2) displaces FOXO4 from the FOXO4-p53 complex Mechanism: FOXO4-DRI binds p53 TAD2 p53 nuclear exclusion p53 mitochondrial translocation BAX activation caspase-3 cleavage senescent cell-selective apoptosis Selectivity basis: FOXO4 is upregulated in senescent cells but expressed at low levels in most non-senescent adult cells selectivity is mechanistically conferred D-amino acid advantage: Proteolytic stability resistant to intracellular peptidases that would rapidly degrade equivalent L-amino acid sequences Structural characterisation: NMR structural models of FOXO4-DRI/p53TAD2 complex resolved (Nature Communications, 2025) confirms disordered-to-ordered transition upon binding Research cell types studied: IMR90 fibroblasts, TM3 Leydig cells, endothelial cells, chondrocytes, keloid fibroblasts, HCT116 cancer cells In vitro working concentration: 25 M used in multiple published studies for senescent cell apoptosis induction What Does FOXO4-DRI Do in Research
b ) Whole homogenate at 3 M, tGSH ( Trkb Penk-WT , 1:00 0.06
Development of tridentate iron chelators: from desferrithiocin to ICL670
Therefore, N-acetylcysteine (NAC) is an effective antidote for APAP poisoning because it provides extra cysteines for GSH synthesis in the liver
1 in womens singles with four Grand Slam titles under her belt, joined IM8 in June and soon after appeared in a viral The Best Choose The Best ad in Times Square and across social media
Published on September 2, 2022 Vitamin D level may affect levels of the Master Antioxidant glutathione, known to help maintain health, protect from toxins, and promote longevity Key Points Glutathione is critical to help protect our cells from damage due to oxidative stress, mercury and other toxic metals, alcohol, persistent organic pollutants
