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There are no human randomized controlled trials (RCTs, studies that randomly assign people to treatments or placebo) of these candidates for lifespan or healthspan yet

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VO 2peak was assessed before and after the 6-week training program via an incremental modified Bruce treadmill graded exercise test

And for the future

Alternatively, we know that these medications reduce the risk of strokes and so it could be that they help by preventing vascular events that contribute to dementia. To explore the possible connection between Alzheimers and GLP-1 agonists, Novo Nordisk launched two phase 3 trials EVOKE and EVOKE plus in 2021