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Clozapine (~3% of patients, often within about two weeks of initiation)

The enzyme was dissolved in phosphate-buffered saline at pH 7.4, sterilized through a 0.22-m membrane, and administered under ultrasound guidance

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Ans : Generally safe, but individuals with specific medical conditions (like G6PD deficiency) should consult a doctor before starting

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On the other hand, the demonstration of paracetamol's progressive hepatic encephalopathy with severe seizures at least partly overruled the general discordance of NSAIDs' adverse effects and therapeutic application, paracetamol in particular as previously mentioned (1-10)