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doi: 10.1172/JCI118621 [DOI] [PMC free article] [PubMed] [Google Scholar] 11.Di Cesare Mannelli L, Ghelardini C, Calvani M, et al

In embryonic Drosophila , the activation of DUOX and subsequent H 2 O 2 production was shown to be triggered by wound-induced calcium (Ca 2+ ) flashes, where Ca 2+ binds to an EF hand Ca 2+ -binding motif of DUOX 72