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Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation

When the researchers switched the subjects to a low-FODMAP diet, their mast cell activation decreased, as evidenced by lower histamine and prostaglandin E2 levels

Expert Opin Drug Saf 18 Yasara N et al (2022) A randomised double-blind placebo-controlled clinical trial of oral hydroxyurea for transfusion-dependent -thalassaemia

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This step-wise structure is standard in peptide research protocols generally: a low starting point, with dose increases spaced out over time rather than jumping straight to a target amount