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(I am a big advocate of spacing out doses for people who have reached their goal weight, OR who are taking GLP-1s primarily for a possible metabolic/anti-inflammatory benefit, and who want to keep their weight neutral.) But maintenance dosing after achieving a clinical response is a completely different concept from starting at a sub-therapeutic dose and hoping it works

The suggested mechanism for the increased risk is the higher incidence of diarrhea and dehydration experienced while taking the drug, leading to increased blood viscosity

There have been isolated case reports of severe toxicity, almost exclusively in situations of extreme overdose or accidental ingestion by small children

Why Cognitive Behavioral Therapy Is the Current Gold Standard of Psychotherapy