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Search terms including asthma together with causes, phenotypes, endotypes, genomics, origins, natural history, pathogenesis, predisposition , provoking factors were used, plus allergic march together with the Global Initiative for Asthma (GINA) and the British Thoracic Society/Scottish Intercollegiate Guidelines Network (BTS/SIGN) guidelines, references contained within the articles found plus articles in the collections of the authors