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5mCG is mainly located at intergenic regions, repetitive DNA regions, and silenced genes, directly interfering with the binding of certain transcriptional regulators to their cognate DNA sequences or recruiting repressive methyl-CpG binding domain (MBD) proteins [33, 35]

Diarrhea from GLP-1 therapy is typically mild-to-moderate, temporary, and manageable with dietary adjustments and lifestyle strategies

Cochrans Q test and the I -squared statistic were used (Page et al., 2021b)to assess the heterogeneity

The cause is usually physiological adaptation, changes in lifestyle factors, or the need for a longer-term treatment strategy

When you start semaglutide therapy, your body undergoes significant metabolic changes

Both may support appetite control and weight loss, but the best option depends on your health history, lab work, and goals