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UC-MSCs treatment has been shown to significantly improve ovarian function and restore hormone secretion and follicular development in chemotherapy (CTX)-induced POI

194,195 The activated PI3K catalyzes the conversion of membrane phospholipid Phosphatidylinositol-4,5-bisphosphate (PIP2) into Phosphatidylinositol-3,4,5-trisphosphate (PIP3)

Global sensitivity analysis is then applied to examine the model behavior and identify the pathways with the greatest impact in control compared to RP conditions

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