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Although clascoterone and spironolactone have similar chemical structures with a 4-ring backbone similar to that of DHT, 29,45 these compounds differ somewhat in their mechanisms of action (Figure 1) and are not considered to be substitutable with each other for clinical use

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For clinicians, GLP-1 RAs may be a pragmatic consideration in HS management where weight loss is a goal and comorbid metabolic risk is present, pending confirmatory evidence

Norepinephrine reuptake inhibition: Increases metabolic rate (thermogenesis) Enhances fat oxidation Suppresses appetite centrally Increases energy expenditure Also increases heart rate and blood pressure (side effects) 3

Address sleep and stress Poor sleep and chronic stress increase cortisol, which promotes fat storage

L-Glutathione Reduced This is a laboratory product for research use only