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FDAs staff reviewers said before the meeting that they couldnt find strong evidence to support any of those uses

Cerebrolysin: Clinical TBI protocols range from 10 mL to 50 mL daily, administered intravenously or intramuscularly

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J Med Chem 2020, 63:66796693

Liquid formulations spoil faster, either because of contamination or photolysis

Tirzepatide is the older, fully matured story: a single-molecule dual incretin agonist taken from discovery through Phase 1 proof-of-concept, [7] then through the large SURPASS (diabetes) and SURMOUNT (obesity) Phase 3 programs, and finally to FDA and EMA approval