58 GLP-1RAs potentially may reduce the risk of AF onset and progression through direct and indirect effects on atrial remodelling, including a reduction in systemic inflammation, improvement of cardiomyocyte metabolism, autonomic nervous system modulation, regulation of intracellular Ca 2+ levels and prevention and possibly reversion of atrial fibrosis
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This agrees with a study conducted by Farahatet and colleagues, and Moin and colleagues who stated that skin types III-IV is a risk factor with negative therapeutic outcome in melasma treatment
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Monti, J
