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These mutations alter the activity of the encoded enzymes such that instead of converting isocitrate to 2-oxoglutarate (-ketoglutarate), while also generating NADPH, the mutant IDH enzymes reduce 2-oxoglutarate (-ketoglutarate) to 2-hydroxyglutarate (2-HG) while simultaneously oxidizing NADPH to NAPD +

10.1016/j.bbabio.2017.04.002 Biochim

Again, this is a very personal decision - one that should be made in conjunction with your doctor

Various studies have confirmed that the S-Acetyl form is better absorbed through the intestinal wall, as its acetyl bond prevents oxidation and helps the molecule to enter the cells directly after absorption in the intestine

This is a community formulation pattern, not a tested combination

Maggie was 300 lbs