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-KG is an essential cofactor for -KG-dependent dioxygenases and is required for DNA and histone demethylation (amino acids involved in epigenetic modification will be addressed in section Amino Acid Metabolism and Epigenetics)

Because ALA is light-sensitive, pharmacies often provide it in light-resistant packaging and it should be administered shortly after preparation to ensure stability

HangauerMJViswanathanVSRyanMJBoleDEatonJKMatovAet al

10.1016/0304-3959(92)90041-9 14 KisoT.WatabikiT.TsukamotoM.OkabeM.KagamiM.NishimuraK.et al (2008)

Exclusion Criteria The exclusion criteria were as follows: Type 1 diabetes mellitus

Published 2024 Feb 5