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Which HRT delivery methods are affected Affected by GLP-1 medications (oral delivery): Oral estrogen tablets (conjugated equine estrogens, estradiol) Oral progesterone (micronized progesterone, such as Utrogestan) Oral progestins (norethisterone, medroxyprogesterone) Oral testosterone (testosterone undecanoate) NOT affected by GLP-1 medications (non-oral delivery): Transdermal estrogen patches Topical estrogen gels and creams Vaginal estrogen rings or suppositories Progesterone-releasing IUD (Mirena) Transvaginal progesterone Testosterone injections Testosterone pellets Testosterone patches or gels The distinction is simple
Tirzepatide is highly bound to plasma albumin (99%)
Vegans and Vegetarians If you follow a vegan or vegetarian diet, you are at a heightened risk of B12 deficiency
The mechanism difference explains nearly every downstream difference including why one consistently produces more weight loss than the other
Girish 2009)
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