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Beyond the head-to-head comparison between GLP-1RA and SGLT-2i, there is an increasing interest in the evaluation on whether the combination of these two classes of drugs will provide additional benefit on cardiovascular outcomes beyond the use of only one of the two classes

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A major challenge was that native GLP-1 is rapidly degradedwithin about two minutesby the enzyme dipeptidyl peptidase-4 (DPP-4)

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