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To become active again, it needs to be "reduced" (recharged) by other nutrients

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Usually mild and reversible

The researchers surmised that the typical reduction of glutathione in the elderly was due to a lower supply of glycine and cysteine, the precursors to glutathione synthesis, and that upon supplementation, they had the ability to stimulate synthesis and restore levels

[6] Greater Functional Benefits The enhanced absorption profile of PureWay-C isn't just about higher blood levels -- it translates to real functional benefits: Superior immune support : By achieving higher concentrations in immune cells, PureWay-C provides better protection against xenobiotic-induced T-cell hyperactivation, potentially reducing inflammatory responses

Her CD57 is quite low, history of Epstein-Barr, Hashimotos and my best guess is that she has Lyme but is not consistent with her treatments